Hair growth effect of outdoor grown Agaricus (strain KA21), Conference Presentation

We made a conference presentation about the effect of King Agaricus at the 39th Annual Meeting of Japanese Society of Clinical Veterinary Medicine on November 17th, 2018.


Hair growth effect of outdoor grown Agaricus (strain KA21)

Akitomo Motoi, Toei Shinyaku Co.,Ltd.

Katsuya Tajima, Tokyo University of Pharmacy and Life Sciences.

Rina Motoi, Toei Shinyaku Co.,Ltd.


We investigated the hair growth effect of outdoor grown Agaricus (strain KA21) in mice.

BALB/c, C3H/HeJ, and C57BL/6J mice were partially shaved to create mouse models for hair loss. Partially shaved BALB/c mice were given oral 5-FU for 5 days to create mouse models for chemotherapy-induced hair loss. These mice were fed AIN93G (control), indoor grown Agaricus 3% (KAID), or outdoor grown Agaricus 3% (KAOD) and their rates of hair growth were measured. Results indicated hair growth promotion in the KAOD group compared to control across all mouse strains. In the KAID group, C3H/HeJ mice had weaker hair growth activity compared to those in the KAOD group, and hair growth was also weak in C57BL/6J mice, while hair growth activity was seen in BALB/c mice. In the chemotherapy-induced hair loss model, outdoor grown Agaricus (strain KA21) demonstrated higher hair growth effect compared to AIN93G and indoor grown Agaricus. Because the basic structure and development mechanisms of hair follicles are very similar across species, outdoor grown Agaricus is likely to promote hair growth in humans, dogs, and cats, and by improving hair loss caused by stress, aging, or drug administration, may lead to better QOL.