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Evidence

We are the best Agaricus research company.

We have research King Agaricus for more than 20 years and published 28 academic papers.


 icon-file Main Evidence

●Anti-Tumor
Biol.pharm.Bull.24(7)820-828(2001)
Antitumor β-Glucan from the Cultured Fruit Body of Agaricus Blazei
○Naohito Ohno,* Mai Furukawa, Noriko N. Miura, Yoshiyuki Adachi,Masuro Motoi, and Toshiro Yadomae

anti-tumor activity (pdf)

●Improve immunity(NK cell activity), Safety Data, Improve Diabetes and Metabolic syndrome.
【Human Trial】

Evidence―based Complementary and Alternative Medicine(Oxford Journals)(eCAM Advance Access published April 12,2007)
Immunomodulating activity of Agaricus brasiliensis KA21 in mice and in human volunteers
○Ying Liu、Yasushi Hukuwatari、Ko Okumura、Kazuyoshi Takeda、Ken-Ichi Ishibashi、Mai Furukawa、Naohito Ohno、Kazu Mori、Ming Gao、Masurou Motoi

improve immunity (pdf)

●Improve QOL (reduce fatigue, stop hair loss, better sleep)
【Human Trial】

International Journal of Medicinal Mushrooms, 17(9) 799-817(2015)
Open-Label Study on the Influence of Food Containing the Royal Sun Mushroom, Agaricus brasiliensis KA21 (Higher Basidiomycetes ), on the Quality of Life of Healthy Human Volunteers
○Motoi M, Motoi A, Yamanaka D, & Ohno N

improve QOL (pdf)

●Improve Diabetes
Journal of Clinical Biochemistry and Nutrition(Advance Publication 2011)
Ipomoea batatas and Agarics blazei ameliorate diabetic disorders with therapeutic antioxidant potential in streptozotocin-induced diabetic rats
○Atsuko Niwa, Takashi Tajiri and Hideaki Higashino

●Protect Liver, Compare with House Agaricus
BMC Complement Altern Med. 2014 Nov 24;14:454. doi:10.1186/1472-6882-14-454.
Differences in antioxidant activities of outdoor- and indoor-cultivated Agaricus brasiliensis, and protective effects against carbon tetrachloride-induced acute hepatic injury in mice.
○Yamanaka D, Motoi M, Motoi A, Ohno N

protect liver (pdf)

●Protect Heart, Improve Circulatory Function, Improve Hypertension
Journal of Medicinal Food 17 (3) 295-301 (2014)
Agaricus brasiliensis KA21 Improves Circulatory Functions in Spontaneously Hypertensive Rats
○Tubone H, Makimura Y, Hanafusa M, Yamamoto Y, Tsuru Y, Motoi M, Amano S

Improves Circulatory Functions (pdf)

●Anti-Fungal Infection in Human
【Human Trial】

International Journal of Medicinal Mushrooms,Vol.11(2) pp117-131(2009)
『Effect of Oral Administration of Dried Royal Sun Agaricus, Agaricus brasiliensis S.Wasser et al. (agaricimycetideae), Fruit Bodies on Anti-β-GlucanAntibody Titers in Humans』
○Ken-ichi Ishibashi, Masuro Motoi, Ying Liu, Noriko N.Miura, Yoshiyuki Adachi, and Naohito Ohno

anti-fungal infection in human (pdf)

●Anti-Fungal Infection in Animais
Jpn. J. Med. Mycol. Vol.51, 99-107 (2010)
『Anti-fungal Cell Wall β-glucan Antibody in Animal Sera』
○Ken-ichi Ishibashi, Chikaku Dogasaki, Masuro Motoi, Noriko Miura,Yoshiyuki Adachi, Naohito Ohno

anti- fungal infection in animals (pdf)


  icon-file Evidence

Biocontrol Science, 2017, Vol.22, No.3, 171-174
『In Vitro Anti-Influenza Virus Activity of Agaricus brasiliensis KA21』
○Nao Eguchi, Kan Fujino, Khompakorn Thanasut, Motoko Taharaguchi, Masuro
Motoi, Akitomo Motoi, Kenji Oonaka, Satoshi Taharaguchi


International Journal of Medicinal Mushrooms, 17(9) 799-817(2015)
『Open-Label Study on the Influence of Food Containing the Royal Sun Mushroom, Agaricus brasiliensis KA21 (Higher Basidiomycetes ), on the Quality of Life of Healthy Human Volunteers』
○Motoi M, Motoi A, Yamanaka D, & Ohno N


Journal of Functional Foods 6 513-522 (2014)
『Effect of polymeric caffeic acid on antitumour activity and natural killer cell activity in mice』
○Yamanaka D, Tajima K, Adachi Y, Ishibasi K, Miura NN, Motoi M, Ohno N


Journal of Medicinal Food 17 (3) 295-301 (2014)
『Agaricus brasiliensis KA21 Improves Circulatory Functions in Spontaneously Hypertensive Rats』
○Tubone H, Makimura Y, Hanafusa M, Yamamoto Y, Tsuru Y, Motoi M, Amano S


BMC Complement Altern Med. 2014 Nov 24;14:454. doi:10.1186/1472-6882-14-454.
『Differences in antioxidant activities of outdoor- and indoor-cultivated Agaricus brasiliensis, and protective effects against carbon tetrachloride-induced acute hepatic injury in mice.』
○Yamanaka D, Motoi M, Motoi A, Ohno N


International Journal of Medicinal Mushrooms, 16, 375–393 (2014)
『Cloning and Characterization of Laccase DNA from the Royal Sun Medicinal Mushroom, Agaricus brasiliensis (Higher Basidiomycetes)』
○Akiko Matsumoto-Akanuma, Satoshi Akanuma, Masuro Motoi, Akihiko Yamagishi,and Naohito Ohno


Food Chemistry 141 (2013) 4073-4080
『Modulation of interferon-γ synthesis by the effects of lignin-like enzymatically polymerized polyphenols on antigen-presenting cell activation and the subsequent cell-to-cell interactions』
〇Daisuke Yamanaka, Masuro Motoi, Ken-ichi Ishibashi, Noriko N. Miura, Yoshiyuki Adachi, Naohito Ohno


International Journal of Medicinal Mushrooms 2013;15(4):335-43.
『Royal Sun Medicinal Mushroom, Agaricus brasiliensis Ka21 (Higher
Basidiomycetes), as a Functional Food in Humans.』
〇Yamanaka D, Liu Y, Motoi M, Ohno N


International Journal of Medicinal Mushrooms 2013;15(2):115-26.
『Analysis of the titer and reactivity of antibody/ies against fungal cell
wall β-glucans in human sera.』
〇Ishibashi K, Morita M, Motoi M, Liu Y, Miura NN, Adachi Y, Ohno N


アレルギーの臨床 The Allergy in Practice, 32, 51-55, 北隆館, 2012
『ヒト多検体間における抗βグルカン抗体力価と反応性』
元井益郎、石橋 健一、大野 尚仁


International Journal of Medicinal Mushrooms 2012;14(2):135-48.
『Safety study of culinary-medicinal Royal Sun Agaricus, Agaricus brasiliensis S. Wasser et al. KA21 (higher Basidiomycetes) assessed by prokaryotic as well as eukaryotic systems.』
〇Motoi M, Ohno N


International Immunopharmacology Available online 8 August 2012
『Agaricus brasiliensis-derived β-glucans exert immunoenhancing effects via
a dectin-1-dependent pathway』
〇Daisuke Yamanaka, Rui Tada, Yoshiyuki Adachi, Ken-ichi Ishibashi, Masuro Motoi, Yoichiro Iwakura, Naohito Ohno


PLoS ONE. (2012) 7(4): e36025.
『The Effect of Enzymatically Polymerised Polyphenols on CD4 Binding and Cytokine Production in Murine Splenocytes』
〇Daisuke Yamanaka, Yumi Tamiya, Masuro Motoi, Ken-ichi Ishibashi, Noriko N. Miura, Yoshiyuki Adachi, Naohito Ohno


Immunopharmacology and Immunotoxicology : 1-10. Posted online on 29
Nov 2011.
『Effect of Agaricus brasiliensis-derived cold water extract on Toll-likereceptor 2-dependent cytokine production in vitro』
〇Daisuke Yamanaka, Masuro Motoi, Ken-ichi Ishibashi, Noriko N. Miura,Yoshiyuki Adachi, Naohito Ohno


International Journal of Medicinal Mushrooms, Vol.13(1) pp78-82(2011)
『Partial Purification and Characterization of Polyphenoloxidase from Culinary-Medicinal Royal Sun Mushroom (the Himematsutake),Agaricus blasiliensis S. Wasser et el.(Agaricomycetideae)International Journal of Medicinal Mushrooms, 13(1):78-82(2011)』
○Akiko Matsumoto-Akanuma, Satoshi Akanuma, Masuro Motoi, Akihiko Yamagishi and Naohito Ohno


International Journal of Medicinal Mushrooms 2011;13(2):101-107.

『Characterization of blood β-1,3-glucan and anti-β-glucan antibody in hemodialysis patients using culinary-medicinal Royal Sun Agaricus, Agaricus brasiliensis S. Wasser et al.  (Agaricomycetideae)

〇Keni-ichi Ishibashi, Masaharu Yoshida, Iwao Nakabayashi, Noriko Yoshikawa, Noriko N Miura, Yoshiyuki Adachi, & Naohito Ohno


Journal of Clinical Biochemistry and Nutrition(Advance Publication 2011)
『Ipomoea batatas and Agarics blazei ameliorate diabetic disorders with therapeutic antioxidant potential in streptozotocin-induced diabetic rats』
○Atsuko Niwa, Takashi Tajiri and Hideaki Higashino


Jpn. J. Med. Mycol. Vol.51, 99-107 (2010)
『Anti-fungal Cell Wall β-glucan Antibody in Animal Sera』
○Ken-ichi Ishibashi, Chikaku Dogasaki, Masuro Motoi, Noriko Miura,Yoshiyuki Adachi, Naohito Ohno


International Journal of Medicinal Mushrooms,Vol.11(2) pp117-131(2009)
『Effect of Oral Administration of Dried Royal Sun Agaricus, Agaricus brasiliensis S.Wasser et al. (agaricimycetideae), Fruit Bodies on Anti-β-GlucanAntibody Titers in Humans』
○Ken-ichi Ishibashi, Masuro Motoi, Ying Liu, Noriko N.Miura, Yoshiyuki Adachi, and Naohito Ohno


日本東方医学会 第23巻・第1号 p1-11(2007年5月)
『ブラジル産自然露地栽培Agaricus brasiliensis KA21(King Agaricus 21菌)子実体のヒトでの安全性の検討』
○劉影(天野暁),福渡靖(未病医学研究センター)森和(鈴鹿医療科学大学鍼灸学部) 大野尚仁,石橋健一(東京薬科大学薬学部免疫学教室)元井益郎(東栄新薬株式会社)


Evidence―based Complementary and Alternative Medicine(Oxford Journals)(eCAM Advance Access published April 12,2007)
『Immunomodulating activity of Agaricus brasiliensis KA21 in mice and in human volunteers』
○Ying Liu、Yasushi Hukuwatari、Ko Okumura、Kazuyoshi Takeda、Ken-Ichi Ishibashi、Mai Furukawa、Naohito Ohno、Kazu Mori、Ming Gao、Masurou Motoi


International Journal of Medicinal Mushrooms,(2006)
『Effect of culture conditions on chemicalcomposition and biological activities of Agaricus braziliensis』
○Satoshi Hashimoto, Akiko M. Akanuma, Masuro Motoi, Nobuhiro Imai,Carlos A. Rodrignes, Sachiko Nameda, Noriko N. Miura, Yoshiyuki Adachi,and Naohito Ohno


International Journal of Medicinal Mushrooms,Vol.8 pp115-128(2006)
『Effect of Agaricus braziliensis S.Wasser et al.(Agarico-mycetideae)on Murine Diabetic Model C57Bl/Ksj-db/db』
○Mai Furukawa, Noriko N. Miura, Yoshiyuki Adachi, Masuro Motoi, and Naohito Ohno


International Journal of Medicinal Mushrooms,Vol.8 pp67-76(2006)
『Cloning and characterization of polyphenoloxidase DNA from Agaricus Brasiliensis』
○Akiko Matsumoto-Akanuma, Akihiko Yamagishi, Masuro Motoi,Naohito Ohno


International Journal of Medicinal Mushrooms,Vol.7 pp535-545(2005)
『ANTI β-GLUCAN ANTIBODY IN BOVINE SERA』
○Ken-ichi Ishibashi ,Chikaku Dogasaki,Tsunenori Iriki,Masurou Motoi,Yu-ichiro Kurone,Noriko N MiuraYoshiyuki Adachi,Naohito Ohno


International Journal of Medicinal Mushrooms Vol.6,No.1 pp41-48(2004)
『ANTI β-GLUCAN ANTIBODY IN CANCER PATIENTS』
○Masuro Motoi , Ken-ichi Ishibashi , Noriko N.Miura ,Yoshiyuki Adachi ,Toshiro
Yadomae , Naohito Ohno(School of Pharmacy,Tokyo University of Pharmacy
and Life Science) Osamu Mizukami (Preventive Medicine & Health Education
, Tokyo Advetist Hospital)


pharm pharmacol Lett(2001)2:87-90
『(1→3)-β-D-GLUCAN IN THE FRUIT BODIES OF AGARICUS BLAZEI』
○ Naohito Ohno,Akiko M. Akanuma,Noriko N.Miura,Yoshiyuki Adachi,and Masuro Motoi


Biol.pharm.Bull.24(7)820-828(2001)
『Antitumor β-Glucan from the Cultured Fruit Body of Agaricus Blazei』
○Naohito Ohno,* Mai Furukawa, Noriko N. Miura, Yoshiyuki Adachi,Masuro Motoi, and Toshiro Yadomae