【Press Release】Toei Shinyaku Presents Research on the Hair Growth Effects of King Agaricus KA21 at the Japanese Society of Anti-Aging Medicine

Toei Shinyaku Co., Ltd. (Headquarters: Mitaka City, Tokyo; President: Akitomo Motoi) announces that it has presented the research results on the hair growth effects of its outdoor cultivated Agaricus blazei KA21 strain (=King Agaricus KA21) at the 24th Annual Meeting of the Japanese Society of Anti-Aging Medicine.


King Agaricus KA21

Presentation Title

“Hair Growth Promotion Effect by Oral Intake of Outdoor Cultivated Agaricus blazei KA21 Strain Fruiting Body”

Collaborative Research Institutions

Angfa Co., Ltd.

Laboratory of Immunology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences

Objective of This Research

Agaricus (Agaricus blazei, brasiliensis) is a medicinal mushroom native to Brazil that is rich in β-glucan and has been reported to have various physiological activities. To date, the fruiting body of the outdoor cultivated Agaricus blazei KA21 strain (hereafter referred to as KA21), grown in Brazil, has been reported to improve the coat condition of senior dogs and cats and to reduce hair loss in human clinical trials. This study aimed to verify the hair loss improvement effects demonstrated by KA21 by evaluating the hair growth promotion effects of KA21 using a hair loss model in mice, as well as the impact of different cultivation methods of Agaricus on hair growth effects.

Test Results

Mice that consumed feed containing outdoor cultivated Agaricus showed the highest hair regrowth score, followed by mice that consumed feed containing greenhouse cultivated Agaricus, and then mice that consumed feed without Agaricus.


The test results suggest that the oral intake of the fruiting body of the outdoor cultivated Agaricus blazei KA21 strain may have hair growth-promoting effects, indicating its potential application as a hair growth supplement.

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