Toei Shinyaku Co., Ltd. (Head Office: Mitaka City, Tokyo; President & CEO: Akitomo Motoi) has confirmed through a human clinical trial that intake of the outdoor-cultivated King Agaricus KA21 strain contributes to improvement of symptoms associated with male menopause (Late-Onset Hypogonadism; LOH syndrome), including decreased libido, erectile dysfunction (ED), depressive mood, and reduced muscle strength.
Based on these findings, the Company has obtained a patent covering these effects. This patent is expected to support applications in men’s health supplements, protein products, beverages, and related formulations.
Press Release
Original Japanese: https://www.atpress.ne.jp/news/575710
English： https://en.atpress.com/news/575710
Chinese: https://zh.atpress.com/news/575710
■ Patent Acquisition
Through joint research with the Faculty of Health Sciences, Shigakukan University, Toei Shinyaku confirmed the potential of outdoor-cultivated Agaricus KA21 to improve multiple symptoms associated with male menopause.
Based on these research results, the Company has obtained a patent from the Japan Patent Office titled:
“Composition for Improving Male Menopausal Symptoms Including Decreased Libido, Erectile Dysfunction (ED), Depressive Mood, and Reduced Muscle Strength, and Pharmaceutical and Food/Drink Products for Prevention or Improvement of Male Menopausal Symptoms Containing the Same.”
This patent specifically covers the outdoor-cultivated King Agaricus KA21 strain whose efficacy in improving ED and male menopausal symptoms has been confirmed through human clinical trials.
■ Patent Overview
Patent Number: Patent No. 7818243
Patent Application Number: 2024-109541
Filing Date: July 8, 2024
Registration Date: February 12, 2026
Inventors: Takanori Tada, Akitomo Motoi
Applicants: Toei Shinyaku Co., Ltd.; Shigakukan Educational Corporation
Title of the Invention
Composition for Improving Male Menopausal Symptoms Including Decreased Libido, Erectile Dysfunction (ED), Depressive Mood, and Reduced Muscle Strength, and Pharmaceutical and Food/Drink Products for Prevention or Improvement of Male Menopausal Symptoms Containing the Same.
In relation to this newly acquired patent, we are scheduled to launch NKUP For Men, a men’s health supplement, in late March 2026.
