【Press Release】Publication of Research on King Agaricus KA21 for Fungal Infections (Canine Malassezia)

Toei Shinyaku Co., Ltd. (Headquarters: Mitaka, Tokyo; President: Akimoto Motoi) Announces Publication of Research on Outdoor-Cultivated Agaricus blazei KA21 = King Agaricus KA21 for Fungal Infections (Canine Malassezia) in the Company’s 33rd International Paper.

Title of the paper

Effects of Outdoor-Grown Royal Sun Medicinal Mushroom Agaricus brasiliensis KA21 (Agaricomycetes) Fruiting Body on Canine Malassezia Dermatitis

Publication: International Journal of Medicinal Mushrooms, 26(6):13 – 23 (2024)

URL :https://pubmed.ncbi.nlm.nih.gov/38801085/


Brazil-grown outdoor-cultivated Agaricus brasiliensis KA21 fruiting body (KA21) significantly increases the production of serum anti-beta-glucan antibody. Therefore, KA21 ingestion may be useful for the prevention and alleviation of fungal infections. This study aimed to determine the effects of KA21 in fungal infections in animals. KA21 was administered to nine dogs infected with Malassezia. Notably, the anti-beta-glucan antibody titer remained unchanged or tended to decrease in the oral steroid arm, whereas in the non-steroid arm, antibody titer increased in almost all animals after KA21 ingestion. Dogs showing improved clinical symptoms exhibited increased anti-beta-glucan antibody titers. The results of this study suggest that KA21 ingestion may alleviate the symptoms of Malassezia and other fungal infections and that continuous ingestion may help prolong recurrence-free intervals. Additionally, the ingestion of KA21 during oral steroid dosage reduction or discontinuation may enable smoother steroid withdrawal.

Application of Outdoor-Cultivated Agaricus blazei KA21 as a Pet Supplement for Fungal Infections in Dogs and Cats

In the past, we administered outdoor-cultivated Agaricus blazei KA21 to dogs and cats (n=94) with fungal infections (Malassezia dermatitis, otitis externa, dermatophytosis) and confirmed significant alleviation of symptoms such as itching and hair loss. The satisfaction rate among veterinarians was also high, ranging from 80.6% to 93.1%, as reported at the 25th Annual Meeting of the Japanese Society of Veterinary Dermatology.

Based on the content of this paper and past conference data, the efficacy of outdoor-cultivated King Agaricus KA21 for fungal infections (Malassezia dermatitis, otitis externa, dermatophytosis, etc.) in dogs and cats is expected.

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