Press Release: King Agaricus KA21 Receives Patent Allowance for Improvement of Andropause Including ED and Decreased Libido

Toei Shinyaku Co., Ltd. is pleased to announce that it has received a patent allowance from the Japan Patent Office for the effects of outdoor-cultivated KIng Agaricus KA21 on the improvement of symptoms associated with male Angropause.

Through human clinical trials, Toei Shinyaku has confirmed that intake of outdoor-cultivated King Agaricus KA21 contributes to improvements in multiple symptoms related to male climacteric disorder, including:

  • Decreased libido

  • Erectile dysfunction (ED)

  • Depressive mood

  • Loss of muscle strength

Based on these findings, the company has received a patent allowance, and the patent registration process is currently underway. The patent certificate is expected to be issued in approximately 1 to 1.5 months.

Press Release

Japanese: https://www.atpress.ne.jp/news/572442

English: https://en.atpress.com/news/572442

Chinese: https://zh.atpress.com/news/572442


About the Patent Allowance

This research was conducted through a joint study with the Faculty of Health Science at Shigakkan University, operated by the Shigakkan Educational Foundation.

The Japan Patent Office granted the patent allowance for the following invention:

“A composition for improving male climacteric disorder, including decreased libido, erectile dysfunction (ED), depressive mood, and muscle weakness, and pharmaceutical, food, and beverage products for the prevention and improvement of male climacteric disorder containing the same.”


Patent Summary

  • Patent Application Number: JP 2024-109541

  • Filing Date: July 8, 2024

  • Inventors: Takanori Tada, Akitomo Motoi

  • Applicants: Toei Shinyaku Co., Ltd.; Shigakkan Educational Foundation

  • Title of the Invention:
    Composition for improving male climacteric disorder, including decreased libido, erectile dysfunction (ED), depressive mood, and muscle weakness, and pharmaceutical, food, and beverage products for the prevention and improvement of male climacteric disorder containing the same


Toei Shinyaku Co., Ltd. will continue to advance science-based research and intellectual property development for outdoor-cultivated King Agaricus KA21, contributing to innovations in men’s health, anti-aging, and preventive healthcare.